An accidental emamectin benzoate poisoning in child: A case report

Abstract We report a case of accidental Emamectin Benzoate poisoning in a six‐year‐old child resulting in nausea, vomiting, abdominal pain, and confusion. We did vigorous gastric lavage with saline, activated charcoal, and coconut oil. The other supportive treatment improved the outcome of the patient with complete resolution of symptoms.

her household chores noticed her playing and consuming "JALJEERA" (cumin powder used to fortify beverages) sachets with a glass of water after a regular evening snack. Following to which she started developing repeated bouts of nausea, vomiting, and abdominal pain in next half an hour to an hour and was then brought to ED by her parents. The thirst for the perplexed and not so concluding history of presenting illness got quenched with the multiple probing and discussions with the family members, making them reveal of having several empty sachets at her home. One of the sachets was discovered to be of "LURA" instead of "JALJEERA". The "LURA" comes as a brand name of a sachet of "Emamectin Benzoate 5% SG" (soluble granules). The packaging of "LURA" was similar to a packet of "JALJEERA" that easily led the child to consume the sachet of "Emamectin Benzoate 5% SG". A provisional diagnosis of Emamectin Benzoate Poisoning was made.
Oriented to time, place, and person on examination, she was awake and alert but mildly confused and irritable. Her Glassgow Coma Scale (GCS) score was 13/15 (E3V4M6). Her pulse rate was 94 beats per minute and regular. Her respiratory rate, axillary body temperature, and saturation were 22 per min., 98.4֯ F, and 98% respectively. Pupils were isochoric with normal light reflex. The chest was clear on auscultation. Auscultation of the precordium did not reveal a murmur or any other added sound. The abdomen was soft, flat, and without tenderness or rebound tenderness.
The initial treatment procedure of gastric lavage with 2 L normal saline, 50 g activated charcoal, and 500 ml coconut oil. Adding to it, she was given an intravenous (IV) injection of pantoprazole (@ 20 mg IV stat), ketorolac (@ 15 mg slow IV stat), ondansetron (@ 2 mg IV stat), and hydrocortisone (@ 50 mg slow IV stat) for symptoms management. 30 min following gastric lavage and emergency observation for 6 h, she was shifted to the general medical ward on the same day.
In the medical ward, the nasogastric tube was continued in situ for 24 h. With IV maintenance fluids, she was kept nil per oral (NPO) for next 24 h. The medications pantoprazole (@ 20 mg IV once a day), and ondansetron (@ 2 mg IV three times a day) were continued on the first day withholding the hydrocortisone. The ketorolac (@ 50 mg IV) was planned to give when needed. Vitals (saturation, pulse and respiratory rate and urine output) and systemic examinations (neurological state, chest auscultations, and abdominal palpation) were assessed four-hourly in the ward and were noted to be normal.
The next day of inpatient admission, her symptoms like nausea, vomiting, and abdominal pain improved, and she was more alert and playful. The nasogastric tube was removed, and IV fluids and medications were stopped. Regarding the diet, the oral sips were allowed, followed by liquid, which was gradually advanced to a semisolid and solid diet. Also, the oral medications (pantoprazole @ 40 mg once a day; domperidone @10 mg twice a day; and oral fluids prepared with sachet of oral rehydration solution, ORS @ 1 sachet/1 L water) were continued.
On the third day of admission, she was discharged with proper counseling on the same oral medications for 3 more days, and ORS, and advised to follow-up after 1 week in the clinic.
In follow-up, after 1 week, she did not have any presenting complaints. Vitals and systemic examinations were within the normal limit. Neuropsychiatric evaluation was done which was normal.

| DISCUSSION
In this case, the patient (weight 20 kilogram, BMI: 15.66 kg/m2) ingested a packet of "LURA" (1 packet = 5 g, Emamectin Benzoate 5% w/w), that is, 250 mg/kg of EB. Clinical manifestations were limited to a mild disturbance of consciousness and gastrointestinal distress.
The clinical presentations of EB poisoning involve central nervous system dysfunction and gastrointestinal upset. However, mammalian species are less sensitive to it due to lower GABA affinity and relative impermeability of the blood-brain barrier. 1,2 In animals, there is substantial evidence of behavioral effects like changes in motor activity (tremors, incoordination, ataxia, and lethargy) and neuronal changes in the form of degeneration and vacuolation of the neuronal cytoplasm. The cytoplasmic vacuoles are associated with cellular debris, macrophages, and pyknotic nuclei 4,5 . A fatal case report in humans has been reported after consumption of 500 g of Emamectin Benzoate 5% SG due to pulseless ventricular tachycardia. 6 As EB has no specific antidote, the management of this poisoning is always supportive and symptomatic. As it possesses GABA mimetic activity, the drugs that enhance GABA activity like benzodiazepines, barbiturates, and valproic acid should be avoided. 1,7,8 There is paucity of literature regarding the complete spectrum of manifestations of EB poisoning in human. Similarly, there are no consensus recommendations for the management of EB poisoning. The EB is available as 5% SG. In view of its water solubility nature, we used both coconut oil and activated charcoal for gastric lavage. We assumed that the coconut oil might coat the gastric mucosa to delay the absorption of EB and may additionally prevent damage to the raw mucosa because of anti-ulcer nature of coconut oil in some studies. 9,10 Similarly, the activated charcoal also could delay absorption by adsorption of toxins which is evident from multiple literatures. 11,12 In this case, apart from the gastric lavage, symptomatic and supportive management was provided. This was a mild case of poisoning in which the patient improved quickly. It is important to label and store chemicals like this safely to minimize harm by accidental ingestion.

| CONCLUSION
In the case of Emamectin Benzoate poisoning, vigorous gastric lavage with both activated charcoal and coconut oil can improve the patient's outcome. The rest of the treatment is symptomatic and supportive. Unfortunately, there is no specific antidote for this poisoning.

AUTHOR CONTRIBUTIONS
GKY was involved in management of patient and in the conception of the report, literature review, initial manuscript preparation, editing and submission. DKR, KM, BP, and ARD were involved in the manuscript critique and review, and final manuscript preparation. All authors have read and approved the final manuscript.